Following the events of "The Dark Knight", the Joker is sentenced to Arkham Asylum where he is placed into the hands of Dr. Harleen Quinzel, a slightly wet behind the ears psychiatrist and current replacement for Dr. Jonathan Crane (The Scarecrow).

Spanning over the course of five individual therapy sessions, the Joker slowly peels off Harleen's authoritative mask while molding her into an image he sees more fit- Harley Quinn.